The major causes of thyroid condition in humans are as follows: Graves’ Disease. The most common cause of hyperthyroidism is the autoimmune disorder Graves’ disease. This accounts for 70% of the cases. All rights reserved. The recommendation to check TSH-receptor antibodies (TRAbs) to distinguish Graves' disease from other causes of hyperthyroidism is based on the NICE clinical guideline , the ATA guidelines on hyperthyroidism , the ETA guideline on Graves' hyperthyroidism [Kahaly, 2018], and expert opinion in review articles [De Leo, 2016; Kravets, 2016; Bathgate, 2018; Biondi, 2018]. Inflammation of thyroid gland or thyroiditis is a common cause of Hyperthyroidism. Other causes include toxic nodular goitre (autonomously functioning thyroid nodules that secrete excess thyroid hormone), or drug-induced thyrotoxicosis. Most people with hyperthyroidism develop hypothyroidism as medication causes the thyroid to go from overactive to underactive. Hypothyroidism can be caused by: Autoimmune thyroid disease – the most common cause. Hyperthyroidism Guide: Causes, Symptoms and Treatment Options If you have been trying to lose weight by dieting, you may be pleased with your success until the hyperthyroidism, which has quickened the weight loss, causes other problems. Hyperthyroidism has several causes, including Graves’ disease, thyroid nodules, and thyroiditis— inflammation of the thyroid. Graves' Disease. If you have an overactive thyroid (hyperthyroidism), your thyroid gland produces too much of the thyroid hormones. Normally, the antibodies in your blood go after bacteria, but if you have Graves’ disease, the antibodies turn on your thyroid instead. About 3 in every 4 people with an overactive thyroid gland have a condition called Graves' disease. This is a self-destructive process in which the body’s immune system attacks the thyroid cells as though they were foreign cells. Signs of hyperthryroidism. WebMD does not provide medical advice, diagnosis or treatment. In some cases, hypothyroidism may be caused by genetic problems, leading to irregularities in hormone production. Treatments for hyperthyroidism include antithyroid medications, radioactive ablation, and surgery. An autoimmune disorder called Graves’ disease is the most common cause of hyperthyroidism. What causes hyperthyroidism? Consumption of iodine in abundant amounts or using excessive amounts of thyroid hormone medication also cause hyperthyroidism. Any of the following can cause hyperthyroidism: Autoimmune disease, such as Graves disease or Plummer disease Certain medicines, such as lithium, amiodarone, or aspirin It’s when the butterfly-shaped gland in your neck produces too much thyroid hormone. Many other health problems can cause an overactive thyroid, for example, thyroiditis or taking too many thyroid hormones. If your thyroid gland makes too much T4 and T3, this is defined as hyperthyroidism. Doctors aren’t sure why some people get Graves’ disease, but it tends to run in families. With this condition, your thyroid is swollen for unknown reasons. Graves’ disease is the most common cause of hyperthyroidism in the UK and is much more common in women than in men. Thyrotoxicosis is the condition that occurs due to excessive thyroid hormone of any cause and therefore includes hyperthyroidism. Hypothyroidism occurs when your body doesn’t produce enough thyroid hormones. Two major hormones that affect how your body works are produced in your thyroid. Nobody knows what causes hyperthyroidism, but the following factors have been noted as possible risk factors: Use of cat litter. Symptoms appear slowly, so you may not notice a problem at first but left untreated over a long period, hyperthyroidism can be fatal. Normally, the immune system helps protect your body against viruses, bacteria, and other substances. An increased level of iodine in your body can cause your thyroid to produce excess thyroid hormones. This happens when one or more sections on your thyroid develop lumps that aren’t cancer. This can happen for many different reasons. The thyroid gland has an enormous impact on your health. It’s also more common in young women. Hyperthyroidism means an overactive thyroid gland.When your thyroid gland is overactive it makes too much thyroxine. Mayo Clinic: “Hyperthyroidism (overactive thyroid).”, American Thyroid Association: “Hyperthyroidism (Overactive).”. Graves' disease is an inherited disease (which affects several family members) and is more frequently found in women than in men. It occurs when the immune system attacks the thyroid gland, causing it to enlarge and make too much thyroid hormone. Toxic adenoma occurs when a single nodule on the thyroid gland causes increased thyroid hormone production. An underactive thyroid (hypothyroidism) is when your thyroid gland does not produce enough of the hormone thyroxine (also called T4). Graves’ disease. These lumps can make your thyroid grow bigger and produce too much T-4 hormone. What Are the Treatments for Hyperthyroidism? It causes thyroid hormones to leak into the blood, raising their overall levels and leading to hyperthyroidism. This can occasionally happen if you're taking medicine that contains iodine, such as amiodarone, which is sometimes used to control an irregular heartbeat (arrhythmia). What causes hyperthyroidism? Hyperthyroidism and Graves’ disease. Graves disease is the most common cause of hyperthyroidism. This results in high levels of the 2 main thyroid hormones, triiodothyronine (also called T3) and thyroxine (also called T4) in your body. © 2005 - 2021 WebMD LLC. Next review due: 24 September 2022, high levels of a substance called human chorionic gonadotrophin in your body – this can happen in early pregnancy, a, a pituitary adenoma – a non-cancerous (benign) tumour in the pituitary gland (a gland at the base of the brain that can affect the level of hormones produced by your thyroid). This can occasionally happen if you're taking medicine that contains iodine, such as amiodarone, which is sometimes used to control an irregular heartbeat (arrhythmia). This is thought to be due to varying levels of iodine in the diet. You’re more likely to develop it if you’re a woman, if you’ve had other thyroid problems, or if you’re over the age of 60. It typically runs in families with a history of thyroid disease or other autoimmune conditions. Nodules are usually non-cancerous (benign), but they may contain thyroid tissue, which can result in the production of excess thyroid hormones. Causes of hyperthyroidism. Graves' disease is the most common cause of hyperthyroidism, and can be associated with eye disease (Graves' opthalmopathy). Rarely, it may be caused by a benign pituitary gland tumor which is located at the base of the brain. In Graves’ Disease (also known as … Thyroiditis. … What causes hypothyroidism? In more than 70% of cases, hyperthyroidism is caused by Graves’ disease. Main causes of hyperthyroidism include Graves’ disease, thyroid nodules and thyroiditis. Graves’ disease is the most common cause of hyperthyroidism, accounting for over 70% of cases. Some, however, use the terms interchangeably. It … Hyperthyroidism usually begins slowly but in some young patients these changes can be very abrupt. There are a number of conditions that can cause your thyroid to become overactive. Hyperthyroidism can have multiple causes. The underlying cause of this change is currently unknown, but is very similar to one of the two main causes of hyperthyroidism in humans called ‘toxic nodular goitre’. The extra thyroxine causes many of your body's functions to speed up. Before exploring possible causes, though, it's important that you get a definitive diagnosis of hypothyroidism or hyperthyroidism, if you haven't done so already. If you have a family member with hyperthyroidism, your risk is increased. Graves’ disease is a hereditary condition (passed down through a family). Plummer’s disease is more common in older people. When your thyroid doesn't produce enough hormones, the balance of chemical reactions in your body can be upset. These are called thyroxine (T-4) and triiodothyronine (T-3). There are three main causes of hyperthyroidism in the human body. Hyperthyroidism causes a high metabolism, which has many negative effects on the body. Another important hormone your thyroid produces is called calcitonin, and this helps keep a healthy amount of calcium in your blood. Less commonly, your thyroid can become overactive if lumps (nodules) develop on your thyroid. Close menu, Back to Overactive thyroid (hyperthyroidism). Smoking can also increase your risk of getting it. Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Coronavirus in Context: Interviews With Experts, Sign Up to Receive Our Free Coroanvirus Newsletter, Why Your Body Might Make Too Much Thyroid Hormone, The Thyroid (Human Anatomy): Picture, Function, Definition, Location in the Body, and More. There… The cause of Graves' disease is unknown, but it mostly affects young or middle-aged women and often runs in families. Hyperthyroidism is another name for an overactive thyroid. An overactive thyroid that's caused by a medicine will usually improve once you stop taking that medicine, although it may take several months for your thyroid hormone levels to return to normal. It’s important to work with your doctor to find the cause because it can affect your treatment. This immune system disorder is the most common cause of hyperthyroidism. In contrast, if you have hypothyroidism, you make too little thyroxine; this causes many of the body's functions to slow down.See the separate leaflet called Underactive Thyroid Gland (Hypothyroidism) for … Hyperthyroidism can also be caused by certain types of medication, typically those which contain iodine. Graves' disease is the most common form of hyperthyroidism … These medical conditions can include: Graves’ disease: In this disorder, your immune system attacks the thyroid. Most people with hyperthyroidism have a condition called Graves’ disease. 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